Funding Sources

Active Grants

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Reliable Seizure Prediction Using Physiological Signals and Machine Learning
Description: The focus of this project is to treat seizures and the psychological impact of epilepsy more effectively by providing patients with real-time seizure forecasting.
Funded By: National Institutes of Health(R01)
Grant Duration: 07/01/2015 - 06/30/2020
Principal Investigator: Gregory A. Worrell, M.D., Ph.D.
Title: Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy
Description: The goals of this project is to develop an epilepsy management and therapy platform using Medtronic 's 3rd generation device implantable device, the RC+S.
Funded By: National Institutes of Health(UH2/UH3)
Grant Duration: 09/01/2015 - 08/31/2020
Principal Investigator: Matt Stead, M.D., Ph.D.
Title: Microscale EEG interictal dynamics & transition into seizure in humans & animals
Description: The major focus of this grant is the dynamics of ictogenesis in rodents & human epilepsy (the transition between inter-ictal to ictal states). Dr. Stead is co-director of Mayo Systems Electrophysiology Laboratory.
Funded By: National Institutes of Health(R01)
Grant Duration: 12/01/2012 - 11/30/2017
Principal Investigator: Virend Somers, M.D., Ph.D. CO-I: Gregory A. Worrell, M.D., Ph.D.
Title: Novel Diagnostic & Therapeutic Strategies for Epilepsy and Parkinson Diseases.
Description: The goal is development of a multi-scale EEG recording and analysis to optimally sample cerebral cortex across the relevant spatiotemporal scale.
Funded By: St. Anne 's University Hospital Brno(EU St. Anne 's Collaboration)
Grant Duration: 01/01/2011 - 12/31/2015
Principal Investigator: Michael J. Kahana Ph.D.CO-I: Gregory A. Worrell, M.D., Ph.D.
Title: Memory Enhancement with Modeling, Electrophysiology, and Stimulation (MEMES)
Description: Restoring Active Memory (RAM) is a multi-center project lead by Mike Kahana at UPenn to investigate the use of direct brain stimulation to improve & restore memory in patients. Mayo Clinic is 1 of 8 sites participating.
Funded By: DARPA(N66001)
Grant Duration: 07/16/2014 - 07/15/2018
Principal Investigator: William Stacey M.D., Ph.D. CO-I: Gregory A. Worrell, M.D., Ph.D.
Title: Characterizing High Frequency Oscillations as an epilepsy biomarker with Big Data tools
Description: The focus of this project is to establish HFOs as a clinically viable biomarker of seizures, allowing their translation into clinical EEG and leading to future prospective clinical studies identifying the location and timing of seizure onset.
Funded By: National Institutes of Health(R01)
Grant Duration: 09/01/2015 - 08/31/2020

Industry Grants

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.
Title: Responsive Neurostimulator (RNS) System Long-Term Treatment Clinical Investigation
Description: Multicenter clinical trial investigating brain stimulation. The major goal of this clinical trial is intended to demonstrate ongoing safety and to evaluate the long-term efficacy of the RNS system in treating medically refractory, partial (focal) onset epilepsy.
Funded By: NeuroPace, Inc(15682)
Grant Duration: 11/01/2006 - 10/31/2017

Recently completed grants

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.
Title: Microseizures, Ultra-slow & High Frequency Oscillations: Biomarkers of epilepsy
Description : The major goal of this grant is to map the distribution of high-frequency oscillations and microseizures and correlate the association with seizures origin.
Funded By: National Institutes of Health(R01-NS63039)
Grant Duration: 04/01/2009-04/01/2015

Entrepreneurship

NeuroOne Inc.

NeuroOne Inc. is a Minnesota based startup company focused on providing clinicians the next generation of intracranial electrophysiology recording & stimulation electrodes. NeuroOne Inc. was created in collaboration with Mayo Clinic epilepsy researchers in response to an unmet patient need in epilepsy surgery and intra-operative monitoring.