Active Grants


Mayo-ASU Team Science Grant

Grant Duration: 08/01/2016-07/31/2019

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Mayo-ASU High Resolution Brain Mapping

The goal of this project is to deepen the alliance between Mayo Clinic and ASU, leverage the knowledge and resources of both institutions to improve patient care and attract future center-level external funding.


NIH/NINDS (R01NS 92882-4)

Grant Duration: 05/15/2015-03/31/2020

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Reliable Seizure Prediction Using Physiological Signals and Machine Learning

The goal of this project is to treat seizures and the psychological impact of epilepsy more effectively by providing patients with real-time seizure forecasting.


ICRC (ICRC 2017)

Grant Duration: 01/01/2017-12/31/2020

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Brain Stimulation Diagnostics & Therapeutics

The goal of this research is to advance the science and clinical translation of Brain Stimulation Theranostics for neurological Disease.


Minnesota Partnership (MNP #17.16 )

Grant Duration: 03/01/2018-02/29/2020

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Astrocyte-derived extracellular vesicles: Epilepsy promoters, repressors and brain stimulation

The goal of this project is to study a novel mechanism underlying the antiepileptic effect by focal electrical brain stimulation.


Epilepsy Foundation

Grant Duration: 01/15/2019-01/14/2020

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Biomarker Targeted Stimulation for Epilepsy: A Multicenter Series

Biomarker Targeted Stimulation (BTS) is a novel therapy developed at the Mayo Clinic to treat adult and pediatric patients with drug-resistant epilepsy. The goal of this project will be to accelerate the commercialization and dissemination of this promising therapy.


NINDS (UH3NS 95495-4)

Grant Duration: 04/01/2019-03/31/2021

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy

The goal of this project is to develop an epilepsy management and therapy platform using Medtronic’s 3rd generation device implantable device, the RC+S.


NIH (R01NS 112144)

Grant Duration: 07/01/2019-6/30/2024

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: The glial mechanism for electrical brain stimulation

Our findings will help guide optimization of stimulation with next-generation EBS devices, with the ultimate goal of enhancing efficacy and treatments for patients with neurological disorders.


Epilepsy Foundation

Grant Duration: 10/05/2018–10/04/2021

Principal Investigator: Benjamin (Ben) H. Brinkmann, Ph.D.

Title: Benchmarking Practical Minimally Invasive Seizure Warning and Alert Systems

The goal of this project will be to investigate physiological signals available via non-and minimally-invasive sensors to forecast and detect seizures in patients with epilepsy.


NIH/NINDS (R01R01NS 94399-4)

Grant Duration: 09/01/2015-06/30/2020

Principal Investigator: William C. Stacey, M.D. Ph.D.

Title: Characterizing High Frequency Oscillations as an epilepsy biomarker with Big Data tools

The goal of this project is to establish HFOs as a clinically viable biomarker of seizures, allowing their translation into clinical EEG and leading to future prospective clinical studies identifying the location and timing of seizure onset.


NINDS (R01NS 96761-4)

Grant Duration: 06/01/2018-05/31/2020

Principal Investigator: Bin He, Ph.D.

Title: Electrophysiological Source Imaging of Partial Epilepsy

The goal of the project is to advance the science of noninvasively localize epileptic brain.


NIBIB (R01EB 21027)

Grant Duration: 03/21/2018-01/31/2021

Principal Investigator: Bin He, Ph.D.

Title: Spatio-temporal Dynamic Imaging of Seizure Sources

The goal of the project is to develop and validate novel engineering techniques to directly image seizure onset zone from high density EEG recordings.


R01 (NS097719)

Grant Duration: 05/15/2017–4/30/2022

Principal Investigator: Lara Jehi, M.D.

Title: A Nomogram to Predict Seizure Outcomes after Resective Epilepsy Surgery

Development and validation of a nomogram to predict seizure outcomes after epilepsy surgery. The goal of this project is to study the concept that accurate individualized epilepsy surgery outcome prediction is possible using the nomogram methodology.


NINDS (R21NS 99734)

Grant Duration: 08/15/2017–07/31/2019

Principal Investigator: Lara Jehi, M.D.

Title: Abnormal Interleukin 1-B and Inflammasome Activation as a Mechanism of Seizure Recurrence After Resective Epilepsy Surgery

The goal of this research is to advance the science and clinical translation of seizure recurrence after resective epilepsy surgery.


NINDS (R01NS 88627-7)

Grant Duration: 03/15/2019-03/31/2024

Principal Investigator: LongJun Wu, Ph.D.

Title: The Role of Microglia in Epilepsy

The goal of this project is to advance the science and clinical translation of what role the microglia play in epilepsy.


NINDS (R21 NS 111756)

Grant Duration: 04/15/2019-04/14/2021

Principal Investigator: Charles Howe, Ph.D.

Title: Peri-electrode large molecule microdialysis of the brain during induced seizures in mice, pigs, and humans with epilepsy undergoing resective surgery

The goal of this project is to advance the science and clinical translation of Peri-electrode large molecule microdialysis of the brain during induced seizures in mice, pigs, and humans with epilepsy undergoing resective surgery.


Pending Grants


NIH (U18)

Grant Duration: 10/01/2019-09/30/2022

Principal Investigator: Cadence Neuroscience Inc.

Title: Next-Gen Pain Platform: Integrating Implantable Neural Stimulators, Wearable Sensors, and Computing Devices

The goal of this project is to advance the science and clinical translation of implantable neural stimulators.


NIH

Grant Duration: 04/01/2020-03/31/2025

Principal Investigator: Michal T. Kucewicz

Title:Behavioral and electrophysiological correlates of human verbal memory processing

The goal of this project is to study memory for words at the fundamental level of brain waves, eye movements, and task performance over multiple days of testing in patients with surgically implanted electrodes.


NIH (UG3/UH3NS 112826-1)

Grant Duration: 09/01/2019-08/31/2024

Principal Investigator: Hal Blumenfeld M.D., Ph.D.

Title: Thalamic stimulation to prevent impaired consciousness in epilepsy

The goal of this project is to advance the science and clinical translation of thalamic stimulation to prevent impaired consciousness in epilepsy.


NIH (U24)

Grant Duration: 02/01/2020-01/31/2025

Principal Investigator: Philip Starr, M.D., Ph.D.

Title: Accelerating Dissemination of Implantable Neurotechnology for Clinical Research

The goal of this project is to advance the science and clinical translation of accelerating dissemination of implantable Neurotechnology.


Regenerative Medicine Minnesota

Grant Duration: 05/01/2019-04/30/2021

Principal Investigator: Kristen Zhao, Ph.D.

Title: Characterization of brain and spinal cord plasticity over the course of functional recovery after spinal cord injury

The goal of this project is to advance the science and clinical translation of brain and spinal cord plasticity over the course of functional recovery after spinal cord injury.


NIMH (R01MH 122258-1)

Grant Duration: 11/0/2019-10/31/2024

Principal Investigator: Dora Hermes, Ph.D.

Title: CCRCNS: Processing speed in the human connectome across the lifespan

The goal of this project is to advance the science and clinical translation of the processing speed in the human connectome across the lifespan.


Completed Grants (Within last 3 years)


NIH (UH2NS095495-01)

Grant Duration: 09/01/2015 - 04/30/2019

Principal Investigator: Gregory A. Worrell, M.D., Ph.D.

Title: Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy

This is a public-private partnership funded by the NIH Brain Initiative program. The goal of this project is to develop seizure forecasting using the Medtronic's 3rd generation RC+S implantable device. The device is now implanted in epileptic canines (yrs 1 -3) to demonstrate the feasibility of real-time seizure detection, forecasting, and electrical stimulation and control. In years 4-5 an IDE study in humans will be performed.


NINDS (R01NS 78136-5)

Grant Duration: 09/30/2012-06/30/2018

Principal Investigator: Squire (Matt) M. Stead, M.D., PH.D.

Title: Microscale EEG interictal dynamics & transition into seizure in humans & animals

The goal of this project is to advance the science and clinical translation of EEG interictal dynamics & transition into seizure in humans & animals.


DARPA-RAM

Grant Duration: 06/01/2014-11/18/2018

Principal Investigator: Michael J. Kahana

Title: Restoring Active Memory

Restoring Active Memory (RAM) is a multi-center project lead by Mike Kahana at UPenn to investigate brain stimulation for restoring and enhancing memory. My group at Mayo Clinic is 1 of 5 sites collecting and analyzing data from patients undergoing intracranial EEG monitoring for evaluation of epilepsy surgery.